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Sustained IGF-1 elevation and GH axis activation The most direct human evidence for CJC-1295 comes from the 2006 Phase 1 program by Teichman and colleagues in the Journal of Clinical Endocrinology and Metabolism , comprising two randomized, double-blind, placebo-controlled ascending-dose trials in healthy adults aged 21 to 61 years (first trial: single subcutaneous doses of 1, 2, 4, 8, 15, or 30 mcg/kg or placebo